TakoTsubo Syndrome: A Well-Known Disease but Not Everything Is Clear Yet

Is everything clear about Tako-tsubo syndrome?

INTRODUCTION Tako-tsubo syndrome is a novel cardio-vascular disease affecting predominantly postmenopausal women exposed to unexpected strong emotional or physical stress, in the absence of significant coronary heart disease. It is characterized by acute onset of severe chest pain and/or acute left ventricular failure, ECG-changes, typical left ventricular angiographic findings, good prognosis ...

Epilepsy...The well-known; yet a lot to be known..

Historically, demonic possession and act of spirits were suspected to explain the strange symptoms of epilepsy. Even nowadays, not all symptoms of epilepsy are clear. Some epileptic semiology's are very bizarre reflecting the little we know about human brain. Focal non motor seizures are subjective experiences. Frontal hyper motor seizures can be wrongly diagnosed as agitations. Absence attacks...

“Not Everything That Is Faced Can Be Changed, but Nothing Can Be Changed Until It Is Faced”: A Response to Recent Commentaries

Die—but not just yet

eterochromatin’s repressive hold on DNA transcription can only be relinquished when activators enter the nucleus. Or so the theory goes. But now Vanessa Witte, Andreas Baur (University of Erlangen, Germany), and colleagues find that a heterochromatin component can be pulled from the nucleus by both the HIV protein Nef and activated integrins. “This is a really new concept—that chromatin-associa...

Yet more evidence that osteoarthritis is not a cartilage disease.

I n this issue of the Annals of Rheumatic Diseases, Tan et al report the results of high-resolution magnetic resonance imaging (hrMRI) of interphalangeal joints of 20 subjects who had ‘‘clinically osteoarthritic’’ and painful finger joints for ,l year. The MRI observations are supported by histological and radiographic examination of dissecting room specimens of apparently non-arthritic interph...